| 貨號 | 純度 | 規(guī)格 | 目錄價 | 會員價 | 庫存 | 數(shù)量 | 購買 |
|---|---|---|---|---|---|---|---|
| AK96249-100ul | 50ul | 50ul | ￥1580.00 | 登錄查看 |
|
產(chǎn)品貨號
AK96249
別名
Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin
converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed
angiotensin-converting enzyme 2]
產(chǎn)品名稱
ACE2 (2C1) Mouse Monoclonal Antibody
類別
抗原抗體
基因名稱
ACE2 UNQ868/PRO1885
蛋白名稱
ACE2
推薦應用
WB,IHC,IF
反應種屬
Human,Mouse,Rat
濃度
1 mg/ml
制備方法
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope
specific immunogen.
存儲緩沖液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene ID
59272
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59272
Human Swissprot No.
Q9BYF1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BYF1/entry
Mouse Gene ID
70008
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70008
Mouse Swissprot No.
Q8R0I0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0I0/entry
Rat Gene ID
302668
1 / 2Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302668
Rat Swissprot No.
Q5EGZ1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EGZ1/entry
特異性
This antibody detects endogenous levels of ACE2 at Human, Mouse,Rat
稀釋度
WB 1:500-2000, IHC 1:50-200, IF 1:50-200
參考分子量
120-135kD
運輸及保存條件
-15°C to -25°C/1 year(Do not lower than -25°C)
細胞定位
[Processed angiotensin-converting enzyme 2]: Secreted .; Cell membrane ; Single-pass type I
membrane protein . Cytoplasm . Cell projection, cilium . Apical cell membrane . Detected in both
cell membrane and cytoplasm in neurons. .; [Isoform 2]: Apical cell membrane .
功能
cofactor:Binds 1 chloride ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,enzyme
regulation:Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu,
and EDTA, but not by the ACE inhibitors linosipril, captopril and
enalaprilat.,function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of
unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze
apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In
case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the
spike glycoprotein of both coronaviruses.,induction:Up-regulated in failing heart.,PTM:N
glycosylation on Asn-90 may limit SARS infectivity.,similarity:Belongs to the peptidase M2
family.,subunit:Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike
glycoprotein.,tissue specificity:Expressed in endothelial cells from small and large arteries, and in
arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small
intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and
gastrointestinal system.,
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資料/datasheet
