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(Mouse) Cxcl12 Rabbit Polyclonal Antibody
A-DK14897
(Mouse) Cxcl12 Rabbit Polyclonal Antibody
貨號 純度 規(guī)格 目錄價 會員價 庫存 數(shù)量 購買
A-DK14897-50μl 50μl 50μl ￥1100.00 登錄查看
A-DK14897-100μl 100μl 100μl ￥2000.00 登錄查看
產(chǎn)品詳情

產(chǎn)品名稱

(Mouse) Cxcl12 Rabbit Polyclonal Antibody

英文名稱

(Mouse) Cxcl12 Rabbit Polyclonal Antibody

類別

抗體產(chǎn)品

反應(yīng)種屬

Human, Rat, Mouse

應(yīng)用

WB

別名

Stromal cell-derived factor 1, SDF-1, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, TPAR1, C-X-C motif chemo

kine 12, Pre-B cell growth-stimulating factor, PBSF, Thymic lymphoma cell-stimulating factor, TLSF, Cxcl12, Sdf1

Clonality

Polyclonal

稀釋度

WB 1:4000-1:8000

預(yù)測分子量

11kDa

宿主

Rabbit

同種型

IgG

組織表達

Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at v

arying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart,

 spleen and m

細胞定位

Secreted.

特異性

This Mouse Cxcl12 antibody is generated from a rabbit immunized with a Mouse Cxcl12 recombinant prot

ein.

背景介紹

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to in
duce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine
receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive r
egulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of mo
nocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with
ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of mono
cytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and intern
alization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development;
required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

                           

All lanes : Anti-Cxcl12 Antibody at 1:4000-1:8000 dilution Lane 1: mouse kidney lysates Lane 2: mouse liver lysates Lane 3: human liver lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dil

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